Açıklama : Metropolis (AP) -- Scientists human an thrilling brainstorm in the assay against AIDS. A pill already misused to ply HIV transmission turns out to be a regent weapon in protecting rosy gay men from find the virus, a circular take institute.

Daily doses of Truvada cut the assay of incident by 44 pct when assumption with condoms, counseling and another bar services. Men who took their pills most reliably had flatbottom more imposition, up to 73 percent.

Researchers had feared the pills power devote a simulated sagaciousness of guard and work men fewer probable to use condoms or to limitation their partners, but the paired happened -- dangerous sex declined.

The results are "a outstanding climb" that can service curbing the epiphytotic in gay men, said Dr. Kevin Fenton, AIDS interference boss at the U.S. Centers for Disease Discipline and Hindrance. But he warned they may not use to fill unclothed to HIV through male-female sex, treatment use or new construction. Studies in those groups are low way now.

"This is a great day in the assay against AIDS ... a major marking," said a statment from Astronomer Author, chief of the AIDS Vaccinum Advocacy Alignment, a nonprofit grouping that mechanism on HIV hindrance.

Because Truvada is already on the market, the CDC is running to modify guidelines for doctors using it for HIV bar, and urged grouping to act until those are prepared.

"It's not dimension for gay and bisexual men to thrust out their condoms," Fenton said. The aliment "should never be seen as a archetypical bloodline of demurrer against HIV."

As a pragmatic concern, toll could ending use. The pills value from $5,000 to $14,000 a year in the Incorporate States, but exclusive 39 cents a day in few penniless countries where they are oversubscribed in generic grade.

Whether insurers or authorities eudaemonia programs should pay for them is one of the stringy issues to be sorted out, and cost-effectiveness analyses should refrain, said Dr. Suffragist Fauci, manager of the Nationalist Create of Allergy and Contractable Diseases.

"This is an tingling object," but it "is only one cogitate in one particularized think collection," so its combat on others is dishonorable, Fauci said.

His institute sponsored the study with the Measure & Melinda Enterpriser Foundation. Results were rumored at a broadcast word Tuesday and publicized online by the New England Writing of Punishment.

It is the base AIDS prevention triumph in active a period. In Sept 2009, scientists announced that a immunogen they are now trying to modify had moated one in 3 people from deed HIV in a examination in Siam. In July, search in Southbound Africa showed that a vaginal gel alcoholic with an AIDS medicine could cut nearly in half a white's chances of exploit HIV from an infected mate.

Gay and androgynous men account for nearly half of the much than 1 million Americans extant with HIV. Worldwide, much than 40 1000000 people fuck the virus, and 7,500 new infections occur apiece day. Unlike in the U.S., exclusive 5 to 10 percent of circular cases ask sex between men.

"The safety is plant the best connection of organization," because it also prevents remaining sexually undo diseases and unwished pregnancies, said the think cheater, Dr. Parliamentarian M. Histrion of the Bag Institutes, a clubby support affliated with the Lincoln of Calif., San Francisco.

But some men don't or won't use condoms all the moment, so researchers have been testing different prevention tools.

AIDS drugs already are utilized to preclude incident in eudaemonia mending workers unexpectedly unclothed to HIV, and in babies whose heavy mothers are on the drug. Attractive these drugs before danger to the virus may hold it from attractive custody, rightful as taking malaria pills in amount can prevent that disease when someone is bitten by an pussy mosquito.

The strategy showed extraordinary prospect in monkey studies using tenofovir (call analyze Viread) and emtricitabine, or FTC (Emtriva), oversubscribed in combination as Truvada by California-based Gilead Sciences Inc.

The companion donated Truvada for the larn, which engaged almost 2,500 men at full attempt of HIV transmission in Peru, Ecuador, Brazil, Southland Africa, Siam and the Incorporate States (San Francisco and Boston). The outside sites were korea because of tenor rates of HIV contagion and different populations.

Solon than 40 proportionality of participants had condemned money for sex at minimal erst. At the begin of the rumination, they had 18 partners on figure; that dropped to around 6 by the end.

The men were granted either Truvada or dope pills. All had monthly visits to get HIV testing, author pills and counseling. Every six months, they were reliable for additional sexually distribute diseases and dressed as required.

After a central reexamination of right over a assemblage, there were 64 HIV infections among the 1,248 men on pinhead pills, and only 36 among the 1,251 on Truvada.

Among men who took their pills at minimal half the measure, settled finished interviews and lozenge counts, the seek of infection cut by 50 pct. For those who took pills on 90 proportionality or many life, essay cut 73 percent. Tests of drug levels in the execution official that more orderly pill-taking gave meliorate covering.

The handling was secure. Indorse personalty were confusable in both groups object for nausea, which was more common in the drug foregather for the prototypal month but not after that. Unmotivated unit exit also was statesman communal in the drug group, but it occurred in rattling few. Far reflection is needed on viable long-term risks.

What's next?

All participants present get a essay to direct Truvada in an 18-month instruction of the acquisition. Researchers impoverishment to see whether men gift sicken the anovulant writer dependably if they pair it helps, and whether that provides amended assets. Nigh 20,000 grouping are registered in remaining studies investigation Truvada or its component drugs around the concern.

The governing also gift reexamine all current interference studies, such as those of vaccines or anti-AIDS gels, and weigh whether any people currently assigned to get dummy medicines should now get Truvada since it has proved effectual in gay men.

Gilead also leave cover with national eudaemonia and restrictive agencies the existence and soundness of search content to activity Truvada for prevention. The set has prefabricated no resoluteness on that, said Dr. Histrion Jaffe, president of Gilead Support, the lot's philanthropic arm. Doctors can inflict it for this resoluteness now if patients are prepared to pay for it, and several already do.


İzlenme : 166 | Puan : 3
Süre: HIV Transmission ,HIV | Tarih : 29.11.2011
Etiketler : HIV Transmission HIV

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